Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the (epsilon)4 Allele for Apolipoprotein E (Original Articles)
Reiman, Eric M.; Caselli, Richard J.; Yun, Lang S.; Chen, Kewei; Bandy, Daniel;
Minoshima, Satoshi; Thibodeau, Stephen N.; Osborne, David.
The New England Journal of Medicine
, Mar 21
, Volume: 334 , Number: 12, Page: 752-758
From the Positron Emission Tomography Center, Good Samaritan Regional Medical Center, Phoenix, Ariz. (E.M.R., L.S.Y., K.C., D.B.); the Departments of Psychiatry (E.M.R.) and Radiology (K.C.), University of Arizona, Tucson; the Departments of Neurology (R.J.C.) and Psychology (D.O.), Mayo Clinic, Scottsdale, Ariz.; theDepartment of Computer Science, Arizona State University, Tempe (L.S.Y.); the Division of Nuclear Medicine, University of Michigan, Ann Arbor (S.M.); and the Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minn. (S.N.T.). Address reprint requests to Dr. Reiman at the Positron Emission Tomography Center, Good Samaritan Regional Medical Center, 1111 E. McDowell Rd., Phoenix, AZ 85006. - Supported by grants from the Samaritan Foundation (to Dr. Reiman), the Mayo Clinic Foundation (to Dr. Caselli), the Robert S. Flinn Foundation (to Dr. Reiman), the Department of Energy (DE-FG02-87-ER60561), and the National Institutes of Health (RO1-NS-24896), and by the family of Joe Weinstein. - Presented in part at the Annual Meeting of the American Academy of Neurology, Seattle, May 12, 1995.
Background: Variants of the apolipoprotein E allele appear to account for most cases of late-onset Alzheimer's disease, and persons with two copies ofthe (epsilon)4 allele appear to have an especially high risk of dementia. Positron-emission tomography (PET) has identified specific regions of the brain in which the rate of glucose metabolism declines progressively in patients with probable Alzheimer's disease. We used PET to investigate whether these same regions of the brain are affected in subjects homozygous for the (epsilon)4 allele beforethe onset of cognitive impairment.
- Kaplitt MG, Smith J, Ferrari F, et al. Expression of human apolipoprotein E in rodent brain via an adeno-associated virus vector. Abstr Soc Neurosci 1995;21:1008. abstract.
Copyright 1996 by the Massachusetts Medical Society
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